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The purpose of SIK1 in tumorigenesis. SIK1 is a tumor suppressor gene, which plays a significant regulatory job in GNAS, KRAS mutation and LKB1 deletion mediated tumors. SIK1 inhibits CREB mediated transcription and affects cancer cell proliferation, metabolic reprogramming and inflammatory microenvironment. SIK1 may market most cancers cell anoiki